Robert C. West
Position title: Eugene G. Rochow Professor Emeritus
c/o Department of Chemistry
1101 University Avenue
Madison, WI 53706
- Co-founder and President, Silatronix Inc.
- B.A. 1950, Cornell University
- A.M. 1952, Harvard University
- Ph.D. 1954, Harvard University
PUBLICATIONS & AWARDS
Professor West is no longer taking students.
Research in this group is mainly devoted to compounds of silicon and germanium. We synthesize new and unusual types of compounds, and study their chemical bonding usng electronic spectroscopy, X-ray crystallography, NMR, EPR and muon spin resonance spectroscopy. In addition we are synthesizing organosilicon compounds as electrolytes for batteries and ultracapacitors, and silicon-containing drug molecules, especially for use as anticancer drugs.
1. Silylenes and germylenes, R2Si: and R2Ge:. These compounds are the silicon and germanium counterparts to carbenes, R2C:, and like carbenes they are usually intensely reactive and unstable. In our group we synthesized the first stable silylenes, 1 and 2. 1 is a 6-pi electron molecule, stabilized by aromatic resonance.
These compounds have opened up a new area of silicon chemistry. For example, here are two reactions leading to new classes of compounds:
The silylenes and their metal complexes have catalytic activity, which is just being studied. We will be doing much more research to explore the chemistry of stable silylenes and their germanium and tin analogs.
2. Silicon-containing anticancer drugs. We are synthesizing analogs to known medicinal compounds, in which we introduce a silicon atom at a strategic point. The resulting substance has somewhat different properties from the original drug, and in some cases prove to be much more active. For example, addition of a silicon substitutent to the known antiinflammatory drug indomethacin, 3, produces “silamethacin”, 4 (n = 3, R = CH3). This sila-drug is much more selective and less toxic than 3. It also has highly promising anticancer activity, against pancreatic, ovarian and lung cancer cells. This and other sila-drugs from our laboratories are now being tested for their anticancer activity in mice. We are exploring many opportunities for silicon substitution into other drug molecules.
3. Polysiloxanes. In the polysiloxane polymers (silicones), the main chain consists of alternating silicon and oxygen atoms. The great flexibility of the silicon-oxygen bonds gives these polymers exceptional properties. The group has recently made polysiloxanes with oligo ethylene oxide side chains, which chelate to lithium ions and promote their transport through the polymer. For example:
Dicomb polysiloxanes of this type show the highest lithium ion conductivity yet recorded for a polymeric electrolyte. We have started a company, Silatronix Inc., to to develop new polysiloxane electrolytes for the next generation of high energy density batteries.
4. Muon spin resonance spectroscopy. Muons are antiparticles, present in cosmic rays. For experimentation they are generated in the proton beam of a cyclotron. Muons can bind to unsaturated molecules to create free radicals, in which they behave something like protons. They undergo decay with a lifetime of 2.2 microseconds, to form positrons which can be counted individually. In a magnetic field, this produces a muon spin resonance spectrum Muon spin resonance has been determined for organic molecules, but its application to organometallic molecues is almost unknown. Using the TRIUMF proton cyclotron in Vancouver BC, we have carried out the first muon spin resonance spectra for silicon and germanium centered radicals. Muon spin resonance spectroscopy is a new method for studying organometallic radicals, giving important structural and chemical bonding information To date we have observed muon spin resonance spectra for divalent compounds of Si and Ge (silylenes and germylenes) as well as a compound containing a Si=C double bond. We plan to study many other unsaturated compounds, first of the group 14 elements, and later for many other main group and transition metal organometallic compounds.